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1 (), () () VEGF 20-40 (1- ). VEGF. 40.

56 2 () () VEGF 0 20 (2- ).

VEGF. 40. 57 3 VEGF . 1 2 p0,001; 2 3 p0,01.

3 4, 4 5 ( 2).58 4 () () VEGF 21 40 (3- ).

VEGF. 4058 5 () () VEGF 41 60 (4- ).

VEGF. 40....60 6 () () VEGF 61 85 (5- ).

VEGF. 40....61 7 () () Dll4 20-40 (1- ). Dll4.

40. 63 8 () () Dll4 0 20 (2- ).

Dll4. 40....64 9 Dll4 . 1 2 p0,01; 2 3 p0,01; 3 4 p0,01 ( 2). 4 5 ( 2)64 10 () () Dll4 21 40 (3- ).

Dll4. 4065 11 () () Dll4 41 60 (4- ).

Dll4. 40....66 12 () () Dll4 61 85 (5- ).

Dll4. 40........67 13 () () Jag-1 20-40 (1- ). Jag-1. 40...69 14 Jag-1 . 2 3 p0,01; 3 4 p0,001.

1 2, 4 5 ( 2)...70 15 () () Jag-1 0 20 (2- ).

Jag-1. 40..71 16 () () Jag-1 21 40 (3- ).

Jag-1. 4072 17 () () Jag-1 41 60 (4- ).

Jag-1. 40......73 18 () () Jag-1 61 85 (5- ).

Jag-1. 40..74 19 () () 20-40 (1- ). .

40..76 20 .

2 3 p0,01; 4 5 p0,001 ( 2). 1 2, 3 4 ( 2)...77 21 () () 0 20 (2- ).

. 40..78 22 () () 21 40 (3- ). . 40..78 23 () () 41 60 (4- ). . 40...80 24 () () 61 85 (5- ). . 40.81 25 () () 20-40 (1- ). . 40.83 26 .

1 2 ( 2).

2 3 p0,001; 3 4 p0,001; 4 5 p0,01 ( 2).84 27 () () 0 20 (2- ).

. 40...84 28 () () 21 40 (3- ).

. 40...86 29 () () 41 60 (4- ).

. 40...87 30 () () 61 85 (5- ).

. 40..88 31 , CD31 24 () 3- (). CD31. 40..90 32 , CD31 30 () 58 (). CD31. 40..91 33 CD31- (̱m). p0,001 煅.92 34 24- () 20 (). . 40..93 35 (̱m). p0,001 煅..94 36 28 (), 55 () 78 (). . 40....95 37 CTGF (̱m). p0,001 煅97 38 CGF- 28- () 1 (). CTGF. 40....98 39 CTGF- 50 () 76 (). CTGF. 40

40 , CTGF (̱m). p0,001 煅100 41 41 CTGF- 35 () 57 (). CTGF. 40....101 42 PCNA (̱m). p0,001

煅..103 43 PCNA- 24 () 1 (). PCNA. 40..104 44 PCNA- 35 (), 53 () 80 (). PCNA. 40..105



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